'what is the mechanism affected when panhypopituitarism happen?'?!
Question:
'what is the mechanism affected when panhypopituitarism happen?'?
Answers:
A state in which the secretion of all anterior pituitary hormones is inadequate or absent; caused by a variety of disorders that result in destruction or loss of function of all or most of the anterior pituitary gland. Rare forms of PHP are inherited as autosomal recessive [MIM*262600] or as X-linked recessive [MIM*312000].
It is frequently the result of other problems that affect the pituitary gland and either reduce or destroy its function or interfere with hypothalamic secretion of the varying pituitary-releasing hormones. Panhypopituitarism can be the end result of a variety of clinical scenarios. The signs and symptoms are diverse. Manifestations of congenital anterior hypopituitarism include micropenis, midline defects, optic atrophy, hypoglycemia, and poor growth.
Pathophysiology:
The effects of hypopituitarism in children are dependent on the hormones affected. GH deficiency can result in hypoglycemia and short stature. Gonadotropin deficiency leads to prenatal micropenis and delayed or interrupted puberty in older children. Corticotropin deficiency interferes with normal carbohydrate, protein, and lipid metabolism and may result in weight loss, hypoglycemia, fatigue, hypotension, and death. Thyrotropin deficiency leads to hypothyroidism. Hormonal control of other endocrine organs as well as growth and sex hormones.