How does ketamine work in treating depression?!


Question: It`s a vetinary (and human) anesthetic....... and if it knocks a horse out!..

Its still experimental in the treatment of depression in humans, so trials are under way i hear.. though i may be wrong .When treating patients suffering from complex regional pain syndrome (CRPS) with a low-dose (subanesthetic) ketamine infusion, it was observed that some patients made a significant recovery from associated depression. This recovery was not formally documented, as the primary concern was the treatment of the patient's pain. Needless to say, it was not possible to quantify to what degree depression recovery was secondary to the patient's recovery from CRPS. Based on this result, it was thought that a low-dose (subanesthetic) infusion of ketamine was worth a trial in patients who were suffering from treatment-resistant depression without other physical or psychiatric illness... Hope that helps a bit!


Answers: It`s a vetinary (and human) anesthetic....... and if it knocks a horse out!..

Its still experimental in the treatment of depression in humans, so trials are under way i hear.. though i may be wrong .When treating patients suffering from complex regional pain syndrome (CRPS) with a low-dose (subanesthetic) ketamine infusion, it was observed that some patients made a significant recovery from associated depression. This recovery was not formally documented, as the primary concern was the treatment of the patient's pain. Needless to say, it was not possible to quantify to what degree depression recovery was secondary to the patient's recovery from CRPS. Based on this result, it was thought that a low-dose (subanesthetic) infusion of ketamine was worth a trial in patients who were suffering from treatment-resistant depression without other physical or psychiatric illness... Hope that helps a bit!





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