Does any one know how long it takes for Sam-e to work?!
Question: For me, it took about 2 weeks to fully start working, but it depends on the person.
Answers: For me, it took about 2 weeks to fully start working, but it depends on the person.
I took it for arthritis, and it didn't work. If you are taking it for depression, I actually can't answer to that, since I don't have depression, thus noticed no difference.