Best drug for depression?!

Best drug for depression?

I used to have bad anxiety, now that has gone away and been replaced with depression, i sit in my room all day and have no desire to go out. Please help me out. I have tried Paxil CR, Xanax, Effexor, Lexapro, all with minimal results.

first off, the anxiety hasn't gone away, it is just masked by the depression. Very often anxiety that is not well managed leads to clinical depression. Meds are not the whole answer here. All they do is serve to make it possible to think more clearly, they are not happy pills. You also need to participate in your own recovery through therapy. If you do not uncover and understand what caused your anxiety disorder to begin with, you will not benefit from any meds. That is why you need to see a therapist in conjunction with the medications.