I have a medical question. Why would a man be taking estradiol along with spiron!

I have a medical question. Why would a man be taking estradiol along with spironolactone?

I have a coworker who is seeing a therapist and has recently been put on those medications. Says most of his friends have gone due to not understanding his issues and that he has not told his parents due to they would not understand either. I do know that estradiol is a female hormone so I guess Im wandering if these are something taken for sex changes, men wanting to be women?

A MAN wouldn't be taking oestradiol and spironolactone ; but a transsexual woman would.
Both drugs are often prescribed to transsexual women; oestradiol for it's feminising effects, and spironolactone for it's androgen-blocking effects.

Oestradiol is sometimes prescribed for prostate cancer, and spironolactone is sometimes prescribed for hypertension, but they wouldn't be prescribed together; oestradiol RAISES blood pressure, so they would cancel one another out.