What is methotrexate? What is its mechanism of action?!

Question: Methotrexate is a folic acid analogue which inhibits dihydrofolate reductase and the formation of the 1-carbon carrier needed in purine and thymine synthesis.

This reduces T and B cell activation, apoptosis of activated T cells and less Ab production.

Hope this helps!

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Answers: Methotrexate is a folic acid analogue which inhibits dihydrofolate reductase and the formation of the 1-carbon carrier needed in purine and thymine synthesis.

This reduces T and B cell activation, apoptosis of activated T cells and less Ab production.

Hope this helps!

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Methotrexate (rINN) (pronounced /m?

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