Why pro- oncho genes get turn in to oncho genes in cancer ?!


Question: Why pro- oncho genes get turn in to oncho genes in cancer !?
Answers:
Proto-oncogenes are normal genes that become 'overactive'!. One of the mechanisms that can lead to excessive expression of oncogenes is hypomethylation of DNA!.

When the promoter region of a gene is methylated, it inhibits the expression of the gene!. If the gene is normally inhibited (suppressed) by methylation, hypomethylation of DNA (common in cancer cells) allows the gene to become 'unsuppressed'!. The resulting excessive expression of the gene makes it an "oncogene"!.Www@Answer-Health@Com





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