What's wrong when you have a high level of LDH?!
Question: What's wrong when you have a high level of LDH!?
Lactate Dehydra!.!.!.something!.
It should be at 100-200 and mine came back at 900, what are the most common causes of this!?Www@Answer-Health@Com
It should be at 100-200 and mine came back at 900, what are the most common causes of this!?Www@Answer-Health@Com
Answers:
Elevated LDH levels can mean that you:
(a) are experiencing hemolysis or the breakdown of red blood cells in your body tissues which contain LDH
(b) if your levels remain high for up for several days, it could mean a myocardial infarction (heart attack) is on the way!.
(c) If your blood sample was incorrectly handled, the results may show that you have high levels of LDH even if you don't!. This may be due to erythrocyte damage!.
(d) High levels of LDH may also indicate the presence of cancer cells, which destroy red blood cells found in your body tissues and release LDH into the blood stream!.
(e) In empyema, the LDH levels generally will exceed 1000 units per liter!. Empyema is when fluid fills your lungs, leading to an infection!.
(f) viral meningitis (easily spreads through crowded population, such as college campuses and large urban areas)
(g) encephalitis (caused by moquitoes who carry the disease)
more information about possible causes can be found on the link below!. please discuss your lab results with your doctor!.Www@Answer-Health@Com
(a) are experiencing hemolysis or the breakdown of red blood cells in your body tissues which contain LDH
(b) if your levels remain high for up for several days, it could mean a myocardial infarction (heart attack) is on the way!.
(c) If your blood sample was incorrectly handled, the results may show that you have high levels of LDH even if you don't!. This may be due to erythrocyte damage!.
(d) High levels of LDH may also indicate the presence of cancer cells, which destroy red blood cells found in your body tissues and release LDH into the blood stream!.
(e) In empyema, the LDH levels generally will exceed 1000 units per liter!. Empyema is when fluid fills your lungs, leading to an infection!.
(f) viral meningitis (easily spreads through crowded population, such as college campuses and large urban areas)
(g) encephalitis (caused by moquitoes who carry the disease)
more information about possible causes can be found on the link below!. please discuss your lab results with your doctor!.Www@Answer-Health@Com
Definition
Lactate dehydrogenase, also called lactic dehydrogenase, or LDH, is an enzyme found in the cells of many body tissues, including the heart, liver, kidneys, skeletal muscle, brain, red blood cells, and lungs!. It is responsible for converting muscle lactic acid into pyruvic acid, an essential step in producing cellular energy!.
Purpose
Lactic dehydrogenase is present in almost all body tissues, so the LDH test is used to detect tissue alterations and as an aid in the diagnosis of heart attack, anemia, and liver disease!. Newer injury markers are becoming more useful than LDH for heart attack diagnosis!.
Precautions
Because the LDH enzyme is so widely distributed throughout the body, cellular damage causes an elevation of the total serum LDH!. As a result, the diagnostic usefulness of this enzyme by itself is not as valuable as determination of the five fractions that comprise the LDH!. These fractions are called isoenzymes and are better indicators of disease than is the total LDH!. The fractions are LDH-1, LDH-2, LDH-3, LDH-4, and LDH-5!. A normal total LDH level does not mean that individual isoenzyme levels should not be measured!. Individual isoenzyme ranges can help differentiate a diagnosis!.
Description
When disease or injury affects tissues containing LDH, the cells release LDH into the bloodstream, where it is identified in higher than normal levels!. For example, when a person has a heart attack, the LDH level begins to rise about 12 hours after the attack and usually returns to normal within 5-10 days!. The LDH is also elevated in diseases of the liver, in certain types of anemia, and in cases of excessive destruction of cells, as in fractures, trauma, muscle damage, and shock!.
Cancers can also elevate LDH level!. Additionally, some patients have chronically elevated LDH with no identifiable cause and no apparent consequence!.
Preparation
This test requires a blood sample!. It is not necessary for the patient to fast (nothing to eat or drink) before the test unless the physician requests it!.
Risks
Risks for this test are minimal, but may include slight bleeding from the blood-drawing site, fainting or feeling lightheaded after venipuncture, or hematoma (blood accumulating under the puncture site)!.
Normal results
Reference ranges for total LDH vary from laboratory to laboratory!. Normal values are also higher in childhood!. For adults, in most laboratories, the range can be up to approximately 200 units/L, but is usually found within 45-90 U/L!.
Abnormal results
Due to the fact that many common disease processes cause elevations in the total LDH level, a breakdown of the five different isoenzymes that make up the total LDH is often helpful for diagnosis!. In certain disorders, the total LDH may be within normal limits, but individual isoenzyme elevations can indicate specific organ or tissue damage!. For example, the LDH-2 fraction is normally greater than LDH-1 in the blood!. After an acute heart attack, however, the LDH-1 rises over the LDH-2 in what is known as a "flipped LDH!."
Certain diagnoses can be assisted by determination of the total LDH!. One example is infectious mononucleosis, in which the LDH is usually more elevated than a liver enzyme called AST!. Conversely, in cases of viral hepatitis, the liver enzymes AST and ALT are greatly increased over the LDH!.
Key Terms
Enzyme
A protein that regulates the rate of a chemical reaction in the body, increasing the speed at which the change occurs!.
Isoenzyme
One of a group of enzymes that catalyze the same reaction but are differentiated by variations in physical propertiesWww@Answer-Health@Com
Lactate dehydrogenase, also called lactic dehydrogenase, or LDH, is an enzyme found in the cells of many body tissues, including the heart, liver, kidneys, skeletal muscle, brain, red blood cells, and lungs!. It is responsible for converting muscle lactic acid into pyruvic acid, an essential step in producing cellular energy!.
Purpose
Lactic dehydrogenase is present in almost all body tissues, so the LDH test is used to detect tissue alterations and as an aid in the diagnosis of heart attack, anemia, and liver disease!. Newer injury markers are becoming more useful than LDH for heart attack diagnosis!.
Precautions
Because the LDH enzyme is so widely distributed throughout the body, cellular damage causes an elevation of the total serum LDH!. As a result, the diagnostic usefulness of this enzyme by itself is not as valuable as determination of the five fractions that comprise the LDH!. These fractions are called isoenzymes and are better indicators of disease than is the total LDH!. The fractions are LDH-1, LDH-2, LDH-3, LDH-4, and LDH-5!. A normal total LDH level does not mean that individual isoenzyme levels should not be measured!. Individual isoenzyme ranges can help differentiate a diagnosis!.
Description
When disease or injury affects tissues containing LDH, the cells release LDH into the bloodstream, where it is identified in higher than normal levels!. For example, when a person has a heart attack, the LDH level begins to rise about 12 hours after the attack and usually returns to normal within 5-10 days!. The LDH is also elevated in diseases of the liver, in certain types of anemia, and in cases of excessive destruction of cells, as in fractures, trauma, muscle damage, and shock!.
Cancers can also elevate LDH level!. Additionally, some patients have chronically elevated LDH with no identifiable cause and no apparent consequence!.
Preparation
This test requires a blood sample!. It is not necessary for the patient to fast (nothing to eat or drink) before the test unless the physician requests it!.
Risks
Risks for this test are minimal, but may include slight bleeding from the blood-drawing site, fainting or feeling lightheaded after venipuncture, or hematoma (blood accumulating under the puncture site)!.
Normal results
Reference ranges for total LDH vary from laboratory to laboratory!. Normal values are also higher in childhood!. For adults, in most laboratories, the range can be up to approximately 200 units/L, but is usually found within 45-90 U/L!.
Abnormal results
Due to the fact that many common disease processes cause elevations in the total LDH level, a breakdown of the five different isoenzymes that make up the total LDH is often helpful for diagnosis!. In certain disorders, the total LDH may be within normal limits, but individual isoenzyme elevations can indicate specific organ or tissue damage!. For example, the LDH-2 fraction is normally greater than LDH-1 in the blood!. After an acute heart attack, however, the LDH-1 rises over the LDH-2 in what is known as a "flipped LDH!."
Certain diagnoses can be assisted by determination of the total LDH!. One example is infectious mononucleosis, in which the LDH is usually more elevated than a liver enzyme called AST!. Conversely, in cases of viral hepatitis, the liver enzymes AST and ALT are greatly increased over the LDH!.
Key Terms
Enzyme
A protein that regulates the rate of a chemical reaction in the body, increasing the speed at which the change occurs!.
Isoenzyme
One of a group of enzymes that catalyze the same reaction but are differentiated by variations in physical propertiesWww@Answer-Health@Com