Why might one present signs of splenomegaly and cardiomegaly in cases of sickle !
Question: Why might one present signs of splenomegaly and cardiomegaly in cases of sickle cell disease!?
Answers:
rocken- The reasons are both mechanical!. In sickle cell disease (SCD)!. the sickle cells (SC) abnormal shapes are trapped in the spleen which normally disposes of old red cells!. In SCD, so many abnormal shapes are trapped in the spleen that the greatly increased number of red cells causes the spleen to enlarge early in the disease!. The SC also tend to clog small capillaries and blood bessels!. This causes added stress on the heart to pump harder, and enlarges the hard as it tries to meet body needs!.Www@Answer-Health@Com
Sickle cell disease is an abnormal shape of red blood cells!. The spleen has narrow vessels leading to and from it and its role is (among other things) is to clear derective blood cells!. The difference in shape of sickle cells therefore results in spleonmegaly!. With the heart it results in increased pressure on the pulmonary artery (pulmonary hypertension) and resulting in increased pressure on the right ventricle of the heart!. Hope this helpsWww@Answer-Health@Com