I am looking for the conditions of rhabdomilitus?!

I am looking for the conditions of rhabdomilitus?

A doctor gave me this name of condition I would like to know what it is

Rhabdomyolysis is the condition you are likely making reference to. It is breakdown of the cellular membranes of somatic or skeletal muscle cells resulting in the fairly rapid rise of muscle proteins in the blood. Depending on the degree of protein release and severity of the Rhabdomyoloysis, it may or may not be toxic to your kidneys.

Rhabdomyolysis has several causes which I will list below. It is a potentially significant disorder in that if moderate to severe it potentially will damage your kidneys, rarely but possibly to the point of renal failure.

The clinical signifcance of rhabdomyolysis lies in the potential for harm to the kidneys. The resultant rise in muscle protein in the blood causes the kidneys to attempt to excrete it, however, as the kidneys are designed to retain protein (primarily albumin) it is difficult for them to do this. The muscle protein then begins to obstruct all the microscopic tubules which comprise the renal filtering system causing what is termed Acute Tubular Necrosis. When this occurs, kidney function declines with resultant fluid retention, acid-base abnormalities of the blood, electrolyte abnormalities (sodium, potassium, phosphorus, magnesium) all of which in turn begin to affect other organs such as the heart, intestines, etc.

The primary causes of Rhabdomyolysis are: (not in any particular order)

1. Severe Sepsis Syndrome, including both viral and bacterial infections (such as Septic Shock from say a pneumonia or abdominal infection - an example is Toxic Shock Syndrome).
2. The cholesterol lowering medications known as Statins can cause this but it is very infrequent relative to the number of folks taking these drugs.
3. Trauma, especially if it involves crush injuries where a significant amount of muscle mass is damaged.
4. A comatose state.
5. Post-ictal state (the state following a generalized muscle seizure).
6. Extreme physical exertion.
7. Post-Operative Surgical Trauma.
8. Certain medications other than the Statins.
9. Severe underlying electrolyte abnormalities.
10. Inherited Muscle Enzyme Deficiencies.
11. Endocrinopathies (disorders of endocrine function, of which Diabetes is one).
12. Drug overdoses, both prescription drugs and illegal drugs.
13. Malignant Hyperthermia
14. Neuroleptic Malignant Syndrome
15. Near Drowning/Hypothermia
16 Hypothyroidism
17. Diabetic Ketoacidosis
18. Hypothyroidism

The signs and symptoms of Rhabdomyolysis are:

1. Pigmenturia (the urine becomes very, very dark orange due to the concentration of myoglobin, the muscle protein released into the blood stream during Rhabdomyolysis).
2. Significant to severe myalgias; that is, generalize muscle aching and pain, which can be very severe.
3. Generalized Skeletal Muscle Weakness.
4. Renal Failure.
5. Electrolyte Abnormalities.
6. Metabolic Acidosis.
7. Hypothyroidism
8. Diabetic Ketoacidosis

Treatment of Rhabdomyolysis:

1. Aggressive parenteral (intravenous) fluid resuscitation.
2. Treatment of the underlying illness or causative factor(s).
3. A forced diuresis (causing the patient to excrete large volumes of urine in an attempt to prevent accumulation of myoglobin the the renal tubules).
4. Close monitoring of the patient for the development of Compartment Syndrome (severe edema of an enclosed area of a limb which would worsent muscle death or necrosis but also damage bone and other structures leading to limb necrosis).
5. Alkalinization of the urine - this used to be a standard recommendation but has fallen out of favor as there is no evidence that it is better than using normal saline solution and it carries the risk of calcium phosphate deposition in the renal tubules and worsen hypocalemia (reduced blood calcium).
6. Rarely Hemodialysis.

I hope this is informative.

DrEarp