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Question: What is Pure Hypercholesterolem ?


Answers: What is Pure Hypercholesterolem ?

Polygenic hypercholesterolemia (nonfamilial hypercholesterolemia is the preferred term) is the most common form of elevated serum cholesterol concentrations. Generally, nonfamilial hypercholesterolemia manifests as moderate hypercholesterolemia (240-350 mg/dL) with serum triglyceride concentrations within the reference range. However, practically speaking, the material in this article is also relevant to patients with mixed dyslipidemias with triglyceride levels of less than 350 mg/dL.

This condition is caused by a susceptible genotype aggravated by excessive saturated fat, trans fatty acid, and cholesterol intake (although the actual effect of cholesterol intake is small). The involved genes have yet to be discovered. Nonfamilial hypercholesterolemia is associated with an increased risk for coronary heart disease (CHD), as displayed in Image 1. Recent studies that show the efficacy of cholesterol-reduction strategies in the reduction of CHD events, even in patients with serum cholesterol concentrations of less than 240 mg/dL, suggest that lower cholesterol concentrations should be viewed as desirable





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