What does this mean and could it affect me?!
Question: What does this mean and could it affect me?
I read this on Wikipedia:
The North American ancestry of the X-linked form of the genetic disease, congenital nephrogenic diabetes insipidus, has been traced to Ulster Scots who came to Nova Scotia in 1761 on the ship Hopewell.
In X-linked nephrogenic diabetes insipidus (NDI) the urine of male patients is not concentrated after the administration of the antidiuretic hormone arginine-vasopressin. This disease is due to mutations in the V2 receptor gene that maps to chromosome region Xq28. In 1969, Bode and Crawford suggested that most NDI patients in North America shared common ancestors of Ulster Scot immigrants who arrived in Halifax in 1761 on the ship Hopewell. A link between this family and a large Utah kindred was also suggested. DNA was obtained from 17 affected male patients from the "Hopewell" kindred and from four additional families from Nova Scotia and New Brunswick who shared the same Xq28 NDI haplotype. The Utah kindred and two families (Q2, Q3) from Quebec were also studied. The "Hopewell" mutation, W71X, is a single base substitution (G-->A) that changes codon 71 from TGG (tryptophan) to TGA (stop). The W71X mutation was found in affected members of the Hopewell and of the four satellite families. The W71X mutation is the cause of X-linked NDI for the largest number of related male patients living in North America. Other families (Utah, Q2 and Q3) that are historically and ethnically unrelated bear other mutations in the V2 receptor gene.
In the USA, Ulster Scots are called Scots-Irish or Scotch-Irish.
So does this affect all Scotch-Irish or just the ones in Nova Scotia? Also I'm about 1/4 Scotch-Irish, 1/4 Native American, 1/8 Spanish, 1/8 Other, and around 1/4 English, so would I have less of a chance to get this?
The North American ancestry of the X-linked form of the genetic disease, congenital nephrogenic diabetes insipidus, has been traced to Ulster Scots who came to Nova Scotia in 1761 on the ship Hopewell.
In X-linked nephrogenic diabetes insipidus (NDI) the urine of male patients is not concentrated after the administration of the antidiuretic hormone arginine-vasopressin. This disease is due to mutations in the V2 receptor gene that maps to chromosome region Xq28. In 1969, Bode and Crawford suggested that most NDI patients in North America shared common ancestors of Ulster Scot immigrants who arrived in Halifax in 1761 on the ship Hopewell. A link between this family and a large Utah kindred was also suggested. DNA was obtained from 17 affected male patients from the "Hopewell" kindred and from four additional families from Nova Scotia and New Brunswick who shared the same Xq28 NDI haplotype. The Utah kindred and two families (Q2, Q3) from Quebec were also studied. The "Hopewell" mutation, W71X, is a single base substitution (G-->A) that changes codon 71 from TGG (tryptophan) to TGA (stop). The W71X mutation was found in affected members of the Hopewell and of the four satellite families. The W71X mutation is the cause of X-linked NDI for the largest number of related male patients living in North America. Other families (Utah, Q2 and Q3) that are historically and ethnically unrelated bear other mutations in the V2 receptor gene.
In the USA, Ulster Scots are called Scots-Irish or Scotch-Irish.
So does this affect all Scotch-Irish or just the ones in Nova Scotia? Also I'm about 1/4 Scotch-Irish, 1/4 Native American, 1/8 Spanish, 1/8 Other, and around 1/4 English, so would I have less of a chance to get this?
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