True or false: when vasoconstriction occurs there is less absorption of drugs be!
Question: True or false: when vasoconstriction occurs there is less absorption of drugs bec. of decreased permeability?
A locally administered drug such as an ophthalmic solution which causes vasoconstriction will not be absorb systemically, and/or absorption is considered negligible because of decreased cellular permeability meaning the active ingredient of the drug will not enter the bloodstream for systemic distribution.
Answers:
Best Answer - Chosen by Voters
In the conjunctiva... yes...
However, 30% of the drug will flow unabsorbed down the lacrimal duct, and into your sinuses... which is full of blood vessles... and here the drug as enough total surface area to enter your systemic circulation.
Mostly true.